Exogenous ketones, HDACi, and cancer

Steve Kirsch Uncategorized

I have Waldenstrom’s Macroglobulinemia, a fatal blood cancer that I’ve controlled with an HDAC inhibitor known as LBH-589 (Panobinostat trade name Farydak).

There is evidence to suggest that people can get a similar HDAC-i effect with ketones.

The idea is to keep ketones at > 1mM at least 12hr/day.

You can do this two ways:

1) eating a ketogenic diet as described in Jimmy Moore’s book Keto Claritywhere you are getting 80% to 90% of your calories from fat and the rest from protein (near zero carbs).

2)  1 scoop of KetoCaNa (19g) + 1 tablespoon of caprylic acid (aka “Brain Octane”) would put most people >1mM for a few hours. Both are available at prototypenutrition.com.

Caprylic acid (MCT) acts to delay gastric absorption of the KetoCaNa and further boosts BHB levels longer, so it improves the pharmacokinetic profile.

Dominic D’Agostino is testing exogenous ketones at a dog sanctuary in Texas and seeing impressive results with ketone esters in cases of a broad range of advanced metastatic cancers. “In the dogs what we see is a slow and steady reduction in tumor burden. A more aggressive metabolic protocol is now being started that uses the Ketogenic Diet + ketone supplementation + IV vit C + hyperbaric oxygen + Metformin. If this does not eradicate the cancer it will make it a weakened target for other drugs.”

In addition, metformin activates AMPK. Nobel prize winner James Watson said he takes it to prevent cancer: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447206/